Study: Effect of Mastic supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial
About NAFLD (fatty liver)
Non-alcoholic fatty liver disease (NAFLD) is a build-up of fat in the liver that isn’t caused by alcohol — the most common liver disorder. It is a medical condition diagnosed and managed by a doctor. The research below is provided for information only.
In short: This page summarises a 2021 clinical trial, MAST4HEALTH, which investigated Chios mastic as a non-pharmacological intervention in NAFLD. Mastic has been studied for antioxidant and lipid-related activity, which set the rationale for the trial.
Methods and results
Ninety-eight patients with NAFLD across three countries (Greece, Italy, Serbia) were randomly allocated to either mastic or placebo for 6 months, in a multicentre, randomized, double-blind, placebo-controlled, parallel-group clinical trial. NAFLD severity was assessed by MRI (LiverMultiScan), alongside medical, anthropometric, biochemical, metabolomic and microbiota measures.
Overall, mastic was not superior to placebo for changes in iron-corrected T1 (cT1) and the Liver Inflammation Fibrosis score (LIF) across the whole group. However, after stratifying by BMI, severely obese patients (BMI > 35 kg/m²) showed an improvement in cT1 and LIF on mastic versus placebo. Mastic also increased gut-microbiota dissimilarity (Bray-Curtis index), downregulated Flavonifractor (an inflammation-associated taxon), and decreased certain lipid metabolites (LysoPC 18:1, LysoPE 18:1) and cholic acid versus placebo.
Conclusion
The authors concluded that mastic supplementation improved microbiota dysbiosis and lipid-metabolite levels in patients with NAFLD, while it reduced markers of liver inflammation/fibrosis only in severely obese patients. You can read the full study here.
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Give Mastic 🎁−15%
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4+1 free 🛍️−20%
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4+1 free 🛍️−20%
Mastic+ Prebiotic Economy Long-Term Mastic TherapyExtra large pack of 800 capsules of Chios mastic gum with prebiotics for long-term support of digestion and intestinal microflora.800 capsules × 222 mg/capsulePrevention2 capsules dailyPrice per day≈158 FtLasts400 days63.200 Ft 79.000 Ft -
Value Set 🔥−20%
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Economy Set 🔥−15%
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For the Whole Family ⭐−11%
Mastic Strong&Pure Economy Double PackBest-value twin pack of 480 capsules of 100% pure mastic gum Strong&Pure for intensive, long-term care of the digestive tract.480 capsules × 350 mg/capsulePrevention1 capsule dailyPrice per day≈123 FtLasts480 days59.100 Ft 66.100 Ft -
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Dual Action 🔄
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With prebiotics
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800 mg mastic gum per sachet
Mastic ComfortSachets with mastic gum and inulin for reflux and heartburn – conveniently also away from home.28 sachets × 800 mg/sachetPrevention1 sachet dailyPrice per day≈332 FtLasts28 days9.300 Ft -
Value Pack 📦
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With Vitamin D3 ☀️
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Medium Tears 💎Bag · 10 g
Mastic Chios Raw Tears Medium Size 10 gContains pure mastic gum of medium size. Suitable for chewing and for the kitchen.10 gSizeSMLXLUseVersatilePrice per gramFrom 203 Ft/gFrom 2.400 FtChoose pack -
Medium Tears 💎Tin · 20 g
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Large Tears 💎Bag · 20 g
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Home stool test 🧪
Helicobacter Pylori Stool TestQuick and reliable home test for detecting H. pylori antigen from stool, with results within 10 minutes.Price per test3.000 Ft3.000 Ft -
📦 Box of 20 pcs−9%
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🫒 Olive oil
Traditional Greek Olive Oil Soap with MasticTraditional Greek olive oil soap with mastic gum for gentle cleansing and hydrating the skin.2.500 Ft -
📦 Box of 10 pcs−8%
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100% pure essence 💧
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